Antibiotics for systemic use; Glycopeptide antibiotics
ATC code: J01XA01
Mechanism of action:
Vancomycin is a tricyclic glycopeptide antibiotic that inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units. The drug is slowly bactericidal for dividing microorganisms. In addition, it impairs the permeability of the bacterial cell membrane and RNA synthesis.
Vancomycin is indicated in all age groups for the treatment of the following infections:
- complicated skin and soft tissue infections (cSSTI)
- bone and joint infections
- community acquired pneumonia (CAP)
- hospital acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP)
- infective endocarditis
- bacteraemia that occurs in association with, or is suspected to be associated with, any of the above
Vancomycin is also indicated in all age groups for the perioperative antibacterial prophylaxis in patients that are at high risk of developing bacterial endocarditis when undergoing major surgical procedures.
Vancomycin is indicated in all age groups for the treatment of Clostridioides difficile infection (CDI).