Active substance:
Cefuroxime sodium
Pharmacotherapeutic group:
Antibacterials for systemic use, Second-generation cephalosporins,
ATC code: J01DC02
Mechanism of action:
Cefuroxime inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (PBPs). This results in the interruption of cell wall (peptidoglycan) biosynthesis, which leads to bacterial cell lysis and death.
Therapeutic indications:
Cefuroxime Dr. Eberth is indicated for the treatment of the infections listed below in adults and children, including neonates (from birth).
- Community acquired pneumonia.
- Acute exacerbations of chronic bronchitis.
- Complicated urinary tract infections, including pyelonephritis.
- Soft-tissue infections: cellulitis, erysipelas and wound infections.
- Intra-abdominal infections.
- Prophylaxis against infection in gastrointestinal (including oesophageal), orthopaedic, cardiovascular, and gynaecological surgery (including caesarean section).
In the treatment and prevention of infections in which it is very likely that anaerobic organisms will be encountered, cefuroxime should be administered with additional appropriate antibacterial agents.