Antibacterials for systemic use, macrolides.
ATC code: J01FA10
Mechanism of action:
The mechanism of action of azithromycin is based upon the suppression of protein synthesis by means of binding to the bacterial ribosomal 50S sub-unit, usually resulting in a bacteriostatic effect.
Azithromycin Friedrich Eberth is indicated in adults requiring initial intravenous therapy for the treatment of the following infections caused by azithromycin-susceptible pathogens:
- community-acquired pneumonia, including Legionnaires’ disease
- Pelvic inflammatory disease (PID)
In cases of severe pneumonia/pneumonia requiring intensive care and/or prevailing risk factors, combination therapy (e.g. with a beta-lactam antibiotic) is required. Azithromycin monotherapy is not indicated for complicated infections, particularly infections in which azithromycin-resistant pathogens cannot be ruled out.