Antibacterials for systemic use; macrolides
ATC code: J01FA10
Mechanism of action:
Azithromycin is a macrolide antibiotic belonging to the azalide group. The molecule is constructed by adding a nitrogen atom to the lactone ring of erythromycin A. The chemical name of azithromycin is 9-deoxy-9a-aza-9a-methyl-9a-homoerythromycin A. The molecular weight is 749.0.
The mechanism of action of azithromycin is based upon the suppression of bacterial protein synthesis by means of binding to the ribosomal 50S sub-unit and inhibition of peptide translocation, usually resulting in a bacteriostatic effect.
Azithromycin Dr. Friedrich Eberth is indicated in adults requiring initial intravenous therapy for the treatment of the following infections caused by azithromycin-susceptible pathogens (see section 5.1):
- community-acquired pneumonia including Legionnaires’ disease
- pelvic inflammatory disease (PID)
Consideration should be given to official guidance on the appropriate use of antibacterial agents.