Vancomycin DR. Eberth

Powder for concentrate for solution for infusion or oral solution

Vancomycin DR. Eberth

dosage/strength

dosage form

pack size

 

pharmaceutical
registration number

SmPC

500 mg

Powder for concentrate for solution for infusion or oral solution

1 vial

N1

12472448

Powder for concentrate for solution for infusion or oral solution

5 vials

N2

12472454

Powder for concentrate for solution for infusion or oral solution

10 vials

N3

12472460

1000 mg

Powder for concentrate for solution for infusion or oral solution

1 vial

N1

12472477

Powder for concentrate for solution for infusion or oral solution

5 vials

N2

12472483

Powder for concentrate for solution for infusion or oral solution

10 vials

N3

12472508

Active substance:
Vancomycin hydrochloride

Pharmacotherapeutic group:
Antibiotics for systemic use; Glycopeptide antibiotics
ATC code: J01XA01

Mechanism of action:
Vancomycin is a tricyclic glycopeptide antibiotic that inhibits the synthesis of the cell wall in sensitive bacteria by binding with high affinity to the D-alanyl-D-alanine terminus of cell wall precursor units. The drug is slowly bactericidal for dividing microorganisms. In addition, it impairs the permeability of the bacterial cell membrane and RNA synthesis.

Therapeutic indications:
Intravenous administration

Vancomycin is indicated in all age groups for the treatment of the following infections:

  • complicated skin and soft tissue infections (cSSTI)
  • bone and joint infections
  • community acquired pneumonia (CAP)
  • hospital acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP)
  • infective endocarditis
  • bacteraemia that occurs in association with, or is suspected to be associated with, any of the above

Vancomycin is also indicated in all age groups for the perioperative antibacterial prophylaxis in patients that are at high risk of developing bacterial endocarditis when undergoing major surgical procedures.

Oral administration
Vancomycin is indicated in all age groups for the treatment of Clostridioides difficile infection (CDI).