Tranexamsäure Eberth

Solution for injection

Tranexamsäure Eberth

dosage/strength

dosage form

pack size

 

pharmaceutical registration number

SmPC

100 mg/ml

solution for injection

10 ampoules with 5 ml solution for injection

N2

12489911

100 mg/ml

solution for injection

10 ampoules with 10 ml solution for injection

N2

12489928

Active substance:
Tranexamic acid

Pharmacotherapeutic group:
Antihemorrhagics, Antifibrinolytics
ATC code: B02AA02

Mechanismen of action:
Tranexamic acid exerts an anti haemorrhagic activity by inhibiting the fibrinolytic properties of plasmin. A complex involving tranexamic acid, plasminogen is constituted; the tranexamic acid being linked to plasminogen when transformed into plasmin. The activity of the tranexamic acid-plasmin complex on the activity on fibrin is lower than the activity of free plasmin alone. In vitro studies showed that high tranexamic dosages decreased the activity of complement.

Therapeutic indications:
Prevention and treatment of haemorrhages due to general or local fibrinolysis in adults and children from one year.

Specific indications include:

  • Haemorrhage caused by general or local fibrinolysis such as:
  • Menorrhagia and metrorrhagia,
  • Gastrointestinal bleeding,
  • Haemorrhagic urinary disorders, further to prostate surgery or surgical procedures affecting the urinary tract,
  • Ear-, nose-, throat-surgery (adenoidectomy, tonsillectomy, dental extractions),
  • Gynaecological surgery or disorders of obstetric origin,
  • Thoracic and abdominal surgery and other major surgical intervention such as cardiovascular surgery,
  • Management of haemorrhage due to the administration of a fibrinolytic agent.